We study the reciprocal interactions between the nervous system and cancer.

We apply classical and systems neuroscience techniques to understand the dynamic neural circuits acting in concert to orchestrate malignant disease progression.

 Our work thus far highlights the potential to target bidirectional neuron-glioma communication and network dynamics for therapy and further aims to understand the spatiotemporal dynamics of these circuits throughout tumor development.

Brain metastases outnumber primary brain tumors by 10-fold and are  on the rise. The "seed-and-soil" hypothesis suggests that as cancer cells spread, they acquire the ability to interact with the specific microenvironment of the host organ. 

We aim to understand how brain metastases interact with their microenvironment and clarify the mechanisms by which electrical inputs facilitate metastatic colonization.